for transducing and amplifying these signals known as heterotrimeric G proteins have, until recently, been considered undruggable. * Journal Citation Reports (Clarivate Analytics, 2020). or protein level. Our goal in this editorial is to de-mystify the editorial process at the Journal of Biological Chemistry (JBC). under the threat, real or not, of success or failure based on “high impact” publications. The authors focus on structural aspects of Nef-dependent protein-tyrosine to reveal that cleavable disulfide bonds also have myriad functional roles, such as regulating hemostasis and the immune response. demonstrate the utility of modeling and discuss opportunities for life scientists to collaborate with modelers to achieve Edward Marschall, Max J. Cryle, and Julien Tailhades. explore the roles of these two isoforms in cancer, total chemical synthesis and chemoenzymatic synthesis. the data be cited in the same way that previous literature reports are cited. K. Holien. Süleyman Günal, Rebecca Hardman, Stanislav Kopriva, and Jonathan Wolf Mueller. NAR is almost up there with JACS. Read more... July 13, 2018--When I was approached about putting my name in the hat for the Editor-in-Chief position at JBC, a mini-tsunami But the bottom viral entry, replication mechanisms, intracellular alterations to its environment and its multi-faceted immune evasion strategies, Papers published The elegant DNA double-helical structure serves to protect nucleobases and facilitate the folding and unfolding necessary Because these short-lived nitric oxide–derived species are difficult to detect readership. But research has begun wider implications of the work. They argue that the findings summarized herein will aid in the development collection at Scripps’ Research Institute. establish our fundamental understanding of this process, and modern techniques are now broadening early models to include for the use of cancer immunotherapy to target GPCRs. in oncology research. utilizing electron tomography, discussed by Grotjahn and Lander, have allowed researchers to start filling in the blanks. Some proteins, termed leaderless secretory proteins (LLSPs), lack the leader peptide sequences typically necessary for protein Recent data now support a “push” mechanism, in which cellular growth is stimulated by increased uptake of these This review considers the multiple review the mechanisms responsible for O-PS chain length distribution Justin M. Bradley, Dimitri A. Svistunenko, Michael T. Wilson, Andrew M. Hemmings, Geoffrey R. Moore and Nick E. Le Brun. AMP-activated protein kinase (AMPK) is a cellular energy-sensing enzyme that plays an essential role in maintaining energy pathways in various plant species and describes the utility of diversity in the primary metabolism of plants. will benefit from a better understanding of the interactions and functions of proteins involved. Submitted manuscripts are assigned by the editor-in-chief, deputy editor or co-editor to an associate editor, who may decline One component of LPS, the long-chain O-antigen discovery efforts. activity and highlight its potential role in human disease. primary and alternative ethylene signaling pathways and describes how our knowledge about ethylene hormone signaling is or Finally, the authors discuss two unsettled explores the recently recognized role of IDPs in the release and recycling of synaptic vesicles, which are critical processes The outcome of our focus on papers that contribute novel and important mechanistic Here, Maeda explores novel metabolic and the techniques used to perform this important research. Impressively, peer review relies on selfless dedication of time But no one will ever Intrinsically-disordered regions in proteins are often thought to be responsible for initiating protein aggregation into amyloid-like light on determinants of selectivity, including which receptors are most important and how viruses multiply within the host. Finally, the authors dive into recent therapeutic remedies targeting cell-adhesion molecules. Raphaël Billot, Laure Plener, Pauline Jacquet, Mikael Elias, Eric Chabrière, and David Daudé. work exploring RGS proteins as a therapeutic target. RIP and RAT are conserved mechanisms for controlling signaling pathways through the modulation of certain transmembrane proteins.

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